Genetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG-A goes “Why? Why? Why?”

Genetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG-A goes "Why? Why? Why?".

Intestinal perforation in a patient with paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias.Acute abdominal pain is one of the PNH clinical manifestations due to venous thrombosis of intra-abdominal sites including hepatic, portal, mesenteric, and splenic veins.Eculizumaband allogeneic bone marrow transplantation (BMT) arethe only w...

Reflection in Nursing Education: Why and How?

Introduction: Nursing education should develop autonomy, critical thinking, open-mindedness and sensitivity to others. Reflection seems to be an effective strategy for developing such capabilities in nursing. Therefore, this narrative review study was carried out to explore reflection in nursing education. Methods: Using keywords like reflecting, reflection and nursing reflection, FarsiandEngl...

Paroxysmal nocturnal hemoglobinuria.

Paroxysmal Nocturnal Hemoglobinuria (PNH) literally means to have episodes of hemoglobin in the urine during the night. It is a Coomb's negative rare hemolytic disorder characterized by non-malignant clonal expansion of haemopoietic stem cells due to acquired genetic mutations. A 30 years old male patient presented with 5 years history of transfusion dependent anemia with intermittent episodes ...

Desflurane why this choice?

1. It should have a rapid and smooth onset of action. Efficiency is a particularly important factor in the ambulatory setting [1] 2. There should be a rapid recovery of cognitive functioning without clinically-significant discomfort. Postoperative pain is a major limiting factor in determining when a patient can be discharged home after surgery. 3. The absence of adverse effects such as nausea ...